I would try it with a different cable, as a test (it can be right next to it for the test) and I would try it wirelessly. I had no issues setting up my Almond 3S with multiple Almond 3 devices and with making changes or moving them around. I haven't set one up wired yet however. I would reset the Almond 3S to start and once that is set up, has a connection and is working I would reset the Almond 3 device. Once it is reset just let it do it's thing, there is no need to manually do anything on the Almond 3 and just do the setup from the Almond 3S LCD screen.